Volume 11, Number 4, July-August 2004

Angiotensin II receptor blockers: a new lease of LIFE?
Michael Kirby, Rubin Minhas

Hypertension is a significant risk factor for both coronary artery disease and cerebrovascular disease. Isolated systolic hypertension and left ventricular hypertrophy are well-recognised risk factors for cardiovascular mortality. The management of hypertension in elderly patients, patients with isolated systolic hypertension or left ventricular hypertrophy is discussed in the context of recent British Hypertension Society guidelines, recent trial evidence and an appraisal of the LIFE study results. Compelling indications for the use of angiotensin II receptor blockers in the management of hypertension are examined and the need for combination therapy in achieving satisfactory blood pressure control is established through examination of the trial evidence.

Br J Cardiol 2004;11:315-320.

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